For a detailed description of the parameters, click on the HELP tab above. For more information, you can also refer to the LCD-Composer webserver paper, the original LCD-Composer paper, or the LCD-Composer Github page. Input your LCD sequence (do not include a title or header; max length=1500 residues): Select the number of defining compositional features you would like to use as LCD search parameters: 1 2 3 4 Organism to search for LCDs: Homo sapiens (Human) - UP000005640_9606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - UP000002311_559292 Mus musculus (Mouse) - UP000000589_10090 Rattus norvegicus (Rat) - UP000002494_10116 Drosophila melanogaster (Fruit fly) - UP000000803_7227 Caenorhabditis elegans - UP000001940_6239 Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) - UP000464024_2697049 Escherichia coli (strain K12) - UP000000625_83333 Arabidopsis thaliana (Mouse-ear cress) - UP000006548_3702 Danio rerio (Zebrafish) (Brachydanio rerio) - UP000000437_7955 Dictyostelium discoideum (Slime mold) - UP000002195_44689 Xenopus laevis (African clawed frog) - UP000186698_8355 Gallus gallus (Chicken) - UP000000539_9031 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - UP000002485_284812 Canis lupus familiaris (Dog) (Canis familiaris) - UP000002254_9615 Heterocephalus glaber (Naked mole rat) - UP000006813_10181 Macaca mulatta (Rhesus macaque) - UP000006718_9544 Zea mays (Maize) - UP000007305_4577 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) - UP000008143_8364 Chlamydomonas reinhardtii (Chlamydomonas smithii) - UP000006906_3055 Cavia porcellus (Guinea pig) - UP000005447_10141 Bacillus subtilis (strain 168) - UP000001570_224308 Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri) - UP000000537_312309 Amphimedon queenslandica (Sponge) - UP000007879_400682 Anolis carolinensis (Green anole) (American chameleon) - UP000001646_28377 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) - UP000000591_284811 Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus) - UP000018467_7994 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - UP000001414_226186 Brachypodium distachyon (Purple false brome) (Trachynia distachya) - UP000008810_15368 Branchiostoma floridae (Florida lancelet) (Amphioxus) - UP000001554_7739 Callosobruchus maculatus (Southern cowpea weevil) (Pulse bruchid) - UP000410492_64391 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) - UP000008144_7719 Columba livia (Rock dove) - UP000053872_8932 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) - UP000002149_214684 Daphnia magna - UP000076858_35525 Emiliania huxleyi (Pontosphaera huxleyi) - UP000013827_2903 Gasterosteus aculeatus (Three-spined stickleback) - UP000007635_69293 Gryllus bimaculatus nudivirus - UP000203733_432587 Macrostomum lignano - UP000215902_282301 Marchantia polymorpha (Liverwort) (Marchantia aquatica) - UP000244005_3197 Marchantia polymorpha subsp. ruderalis - UP000077202_1480154 Medicago truncatula (Barrel medic) (Medicago tribuloides) - UP000002051_3880 Mesocricetus auratus (Golden hamster) - UP000189706_10036 Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) - UP000000807_243273 Myotis lucifugus (Little brown bat) - UP000001074_59463 Naegleria gruberi (Amoeba) - UP000006671_5762 Nematostella vectensis (Starlet sea anemone) - UP000001593_45351 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) - UP000001805_367110 Nicotiana tabacum (Common tobacco) - UP000084051_4097 Oikopleura dioica (Tunicate) - UP000001307_34765 Oryza sativa subsp. indica (Rice) - UP000007015_39946 Oryza sativa subsp. japonica (Rice) - UP000059680_39947 Oryzias latipes (Japanese rice fish) (Japanese killifish) - UP000001038_8090 Petromyzon marinus (Sea lamprey) - UP000245300_7757 Physcomitrella patens subsp. patens (Moss) - UP000006727_3218 Poecilia reticulata (Guppy) (Acanthophacelus reticulatus) - UP000242638_8081 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) - UP000006729_3694 Pristionchus pacificus (Parasitic nematode) - UP000005239_54126 Pseudomonas fluorescens (strain F113) - UP000005437_1114970 Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus) - UP000007431_578458 Selaginella moellendorffii (Spikemoss) - UP000001514_88036 Setaria viridis (Green bristlegrass) (Setaria italica subsp. viridis) - UP000298652_4556 Stentor coeruleus - UP000187209_5963 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - UP000001973_100226 Strongylocentrotus purpuratus (Purple sea urchin) - UP000007110_7668 Synechocystis sp. (strain PCC 6803 / Kazusa) - UP000001425_1111708 Taeniopygia guttata (Zebra finch) (Poephila guttata) - UP000007754_59729 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) - UP000005226_31033 Tetrahymena thermophila (strain SB210) - UP000009168_312017 Thalassiosira pseudonana (Marine diatom) (Cyclotella nana) - UP000001449_35128 Tribolium castaneum (Red flour beetle) - UP000007266_7070 Trichoplax adhaerens (Trichoplax reptans) - UP000009022_10228 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) - UP000000561_237631 If your organism does not appear in the dropdown menu, try submitting the scientific name of your organism (e.g. "Homo sapiens"). A full list of supported organsisms can be downloaded here, and you can copy/paste the scientific name of your favorite organism. Include all isoforms in the LCD search?: By default, LCD-Composer will only search the UniProt proteome file that contains one representative protein sequence per gene. Run a GO-term analysis on resulting LCD-containing proteins?: By default, GO-term analysis is not performed. GO-term analysis is only available for select organisms (see "HELP" page for more details). It is recommended that you only run a GO-term analysis once you have finalized your decision on the best LCD search parameters for your hypothesis/application. Otherwise, you may need to consider additional measures for correcting p-values (see "HELP" page).